IVL in High Risk Left-Main PCI

By Muhammad Andi Yassiin, Rajinikanth Rajagopal
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Muhammad Andi Yassiin


Muhammad Andi Yassiin1, Rajinikanth Rajagopal1


Gleneagles JPMC, Brunei Darussalam1
Adjunctive Procedures (thrombectomy, artherectomy, special balloons) - Adjunctive Procedures

IVL in High Risk Left-Main PCI

Muhammad Andi Yassiin1, Rajinikanth Rajagopal1

Gleneagles JPMC, Brunei Darussalam1

Clinical Information

Patient initials or Identifier Number


Relevant Clinical History and Physical Exam

A 62-year-old lady with recent stroke and severe LV impairment was referred for an angiogram. Angiogram showed severe calcified stenosis of LMS and all 3 vessels. She was turned down for surgery. PCI to the RCA was done uneventfully (image) and she was brought back for PCI to LMS/LAD/LCx a week later. In view of the severe calcification, we planned to use Intravascular Lithotripsy +/- Rotablation to aid the PCI with OCT imaging guidance.

Relevant Test Results Prior to Catheterization

ECG: Sinus rhythm, T inverted lateral leads, left ventricular hypertrophyLab: Hb 116 g/L, BNP 2542 pg/ml, Troponin I 0.32 ng/mLEcho: Dilated LV size. Global LV hypokinesia. Normal RV function. TAPSE 1.9 cm. Poor LV systolic function. LVEF 31%. Severe LV diastolic dysfunction. Mild mitral regurgitation. Trivial aortic regurgitation. Trivial pulmonary regurgitation. Mild tricuspid regurgitation. PPG: 25 mmHg. Mild global pericardial effusion / over RA 1.0 cm. No vegetation, thrombus or PFO.

Relevant Catheterization Findings

LM - Distal LM 50%LAD - Severe calcification, with diffuse ostial to mid LAD 60-70%LCx - Severe calcification with ostial LCx 70%, mid LCx 70%RCA - Proximal RCA 80%, mid RCA 70%

Interventional Management

Procedural Step

The PCIwas performed from the Right Radial Access using 6F ‘Slender’ glidesheath and a7F EBU 3.5 guiding catheter. OCT in the LAD showed 270 degrees calcificationnear the diagonal branch. LCx pre-dilated using a 2.0 x 15 mm ‘Sapphire’NC balloon. Unable to pass a 2.5 x 10 mm ‘Wolverine’ cutting balloon. A 2.5 mmIntravascular Lithotripsy passed but slipped repeatedly during inflation.Further pre-dilatation with a 2.5 x 15 mm ‘Sapphire’ NC balloon was done. The2.5 mm ‘Shockwave’ balloon was then used to treat the ostial LCx, expandedafter 50 pulses. The LCx pre-dilated further with a 2.5 x 10 mm cuttingballoon. The same “Shockwave” balloon placed in the LAD ostium backto the LMS and the remaining 30 pulses were delivered with good effect. The LADwas pre-dilated with a 2.5 mm NC balloon. A ‘Xience’ 2.75 x 12 mmDES deployed in LCx, post-dilated with a 3.0 mm NC balloon and crushed with a3.0 mm NC balloon in LM-LAD. Wire recrossed and kissing balloon inflation (KBI)performed. ‘Xience’ 2.25 x 23 mm and 3.0 x 33 mm DES deployed from mid LAD toostial LM, followed by POT with a 3.75 x 12 mm NC balloon in LMS. LAD stents post-dilatedwith a 3.0 mm NC balloon. LCx rewired and KBI was performed with a 2.75 mmballoon in LCx and a 3.0 mm NC balloon in LAD. There was an irregularappearance in LCx ostium. We were unable to pass the OCT catheter. A 3.0 mm NC balloonwas passed into the LCx and a final KBI was performed. Final result wassatisfactory.

Case Summary

In this patient with severe LV impairment and complex LMS bifurcation stenosis, IVL, along with cutting balloon, helped us to treat the heavy calcification effectively and complete a successful DK Crush bifurcation stenting.IVL in the LMS was well tolerated with no hemodynamic compromise during balloon inflations. It is important to observe sufficient intervals between inflations and monitor the pressure carefully.